What defines a gene in the genome? What defines an ORF in a gene? How do you get from 1D to 3D (Protein folding problem)? Relation between structure and function Relations between biomolecules (networks and pathways) How do all these biological machines work together? New algorithms for: data mining, analysis, comparisons, etc. People with math and programming skills to bring fresh approaches and knowledge A whole lot of code to mangle all the data A glimpse of how nature does its thing To find out what those weird scientist are up to Fame, fortune (yeah, sure), and the thrill of discovering and exploring a new knowledge landscape