Bioinformatic Web Applications *must* implement Web Services. Small effort to implement them, and high payoffs in terms of sharing, collaboration, and knowledge integration. Use REST, XML-RPC, SOAP, or the [RPC flavor of the month]. Just keep them nice and simple, your fellow researchers will love you for that. *REST* is the simplest way to share. We've been doing it since the CGI spec appeared. No spec on how to represent the returned data. *XML-RPC* is simple, but data with complex structure might not be easy to represent. *SOAP* is a more complex, but it gives you more flexibility (XML Schemas, RPC and Document Literal, WSDL, Service redirection, etc.) Plan on synchronous and asynchronous access to improve performance. Consider XML Spaces and similar Tuple/Data Spaces. Use the MDB Web Services. Use the MDB Web Services. Use the MDB Web Services...